Chicago
Cubs
Moneyline
-142
MLB Predictions
Chicago Cubs vs Cincinnati Reds Predictions
Saturday, September 19, 2026 at 6:40pm EST at Great American Ball Park, Cincinnati, Ohio
@
Cincinnati
Reds
Moneyline
+118
50%
50%
Spread
Chicago Cubs -1.5
Cincinnati Reds +1.5
Moneyline
Chicago Cubs -142
Cincinnati Reds +118
Total
Over 9.5 (-110)
Under 9.5 (-110)
Who wins this game?
Professional Picks
2 available
Professional Picks On This Game
Carlos Nunez
Total pick
Kit Wilson
Spread pick
Cubs vs. Reds Prediction: Cincinnati’s Pitching Struggles Favor Chicago
Analysis updated September 19, 2026 at 6:50 AM CDT
Chicago’s recent hitting and probable starter Matthew Boyd give it the edge. Whether that edge justifies SPF’s price is less clear.
Reds’ pitching gives Chicago an opening
Cincinnati’s pitching staff has a 7.74 ERA and has allowed 21 home runs over its past 10 games, according to sports news site Bleacher Nation. Chicago has slugged .424 in that stretch against Cincinnati’s .347. That matchup favors the Cubs, who are -138 on SPF’s moneyline, with the Reds at +115.
FanDuel Research, FanDuel’s sports analysis publication, lists left-handers Matthew Boyd and Nick Lodolo as the probable starters. Boyd has a 4.16 ERA for Chicago; Lodolo has a 5.12 ERA for Cincinnati. The comparison strengthens the Cubs’ case, though neither starter is confirmed.
Win pick: Cubs; wager: Pass
Chicago’s -138 price requires a win probability above roughly 58% to break even. The recent results and probable starters make the Cubs the winner pick, but a 10-game sample and an ERA comparison don’t establish that they clear that threshold. Pass on the moneyline.
SPF’s total is 9.5, with over -115 and under -105. Cincinnati’s home-run troubles favor scoring, but its offense has hit just .219 over its past 10 games, per Bleacher Nation. Without confirmed lineups or weather information, the total is also a pass.
Pick
Chicago Cubs
Confidence
low
Betting lean
Pass