NCAAF Predictions

Purdue Boilermakers vs UCLA Bruins Predictions

Saturday, September 19, 2026 at 1:00pm EST

Purdue

Boilermakers

Spread +14
@
UCLA

Bruins

Spread -14
50% 50%
Spread Purdue Boilermakers +14 UCLA Bruins -14
Moneyline Purdue Boilermakers +470 UCLA Bruins -650
Total Over 52.5 (-112) Under 52.5 (-108)

Who wins this game?

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Purdue at UCLA: Tanona out as Bruins lay 14 points

Analysis updated September 19, 2026 at 5:07 AM CDT

Purdue must replace its starting left tackle against a two-touchdown favorite. That absence alone doesn't justify backing UCLA to cover.

Purdue loses a starter on the offensive line

Purdue will be without starting left tackle Joey Tanona at UCLA, adding a protection concern for the 14-point underdog at SPF. Indianapolis Star via Yahoo Sports, a report from the Indianapolis daily newspaper, says Tanona was downgraded from doubtful to out on Friday.

The same report lists Purdue defensive end Elo Modozie as out after he had been questionable. His absence also leaves Purdue replacing a player on defense, though the report doesn't establish how much either replacement will affect the matchup.

Betting outlook

UCLA is the likely winner based on SPF's -650 moneyline, with Purdue at +470. Backing the Bruins at that price requires a win probability above 86.7% to break even. The injury news doesn't establish that probability or provide a reliable estimate of the winning margin, so the recommendation is Pass on both the moneyline and spread.

SPF lists the total at 52.5, with over -112 and under -108. Without current production or pace figures to assess scoring, there's no supported total bet. No score prediction is warranted.

Pick UCLA Bruins
Confidence low
Betting lean Pass
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