SMU
Mustangs
2-0
Spread
+2.5
NCAAF Predictions
SMU Mustangs vs Louisville Cardinals Predictions
Saturday, September 19, 2026 at 3:30pm EST at L&N Federal Credit Union Stadium, Louisville, KY
@
Louisville
Cardinals
Spread
-2.5
50%
50%
Spread
SMU Mustangs +2.5
Louisville Cardinals -2.5
Moneyline
SMU Mustangs +110
Louisville Cardinals -130
Total
Over 58.5 (-112)
Under 58.5 (-108)
Who wins this game?
Professional Picks
3 available
Professional Picks On This Game
SMU at Louisville prediction: SMU's big win doesn't settle the bet
Analysis updated September 19, 2026 at 5:56 AM CDT
SMU's latest result is decisive, but it offers little basis for choosing a side against a narrow home favorite.
Can SMU carry its scoring into Louisville?
SMU enters 2-0 after a 56-10 win over UC Davis on September 12, according to Varsity Slate, a sports schedule site. SPF still lists the Mustangs as 1.5-point underdogs at Louisville. That scoring outburst alone doesn't establish an edge against the Cardinals.
The teams meet September 19 at 3:30 p.m. ET at L&N Federal Credit Union Stadium, per Varsity Slate. SPF prices Louisville at -118 on the moneyline and SMU at -102, making the Cardinals a slight market favorite.
Betting outlook
Pass on the side. Without a current Louisville performance comparison or confirmed personnel information, there's no sound basis for an independent winner pick or a bet on either team.
The total is 58.5, with Over -112 and Under -108 at SPF. SMU's last score supplies no measure of Louisville's defense or this game's likely pace, so the total is also a pass.
Confidence
low
Betting lean
Pass