Missouri
Tigers
5-1
Spread
+5.5
NCAAF Predictions
Missouri Tigers vs Ole Miss Rebels Predictions
Saturday, October 17, 2026 at 3:30pm EST at Vaught-Hemingway Stadium, Oxford, MS
@
Ole Miss
Rebels
4-1
Spread
-5.5
50%
50%
Spread
Missouri Tigers +5.5
Ole Miss Rebels -5.5
Moneyline
Missouri Tigers +185
Ole Miss Rebels -225
Total
Over 58.5 (-112)
Under 58.5 (-108)
Who wins this game?
Professional Picks
5 available
Professional Picks On This Game
Tom Strickland
Total pick
King Jon Sanderson
Total pick
Danny Soros
Spread pick
Scott Steele
Spread pick
Eli Rothstein
Total pick
Missouri vs. Ole Miss Prediction: Tigers’ Run Game Favors +5.5
Analysis updated October 16, 2026 at 8:08 AM CDT
Ole Miss is the likelier winner at home, while Missouri’s rushing matchup makes taking 5.5 points more attractive than paying -225 for the Rebels.
Missouri’s run game can test Ole Miss
Missouri running back Jamal Roberts has 828 rushing yards and leads the Power conferences, according to a Columbia Daily Tribune via AOL scouting report. Ole Miss is allowing 176.4 rushing yards per game. That matchup gives the Tigers a direct way to control possession and stay within the SportsPicksForum spread of +5.5.
Missouri is 5-1 overall and has won consecutive SEC games against Florida and Texas A&M by multiple touchdowns. Ole Miss is 4-1 after responding to its loss at Florida with a 52-17 victory at Vanderbilt. Both teams are 2-1 in conference play entering Saturday’s game at Vaught-Hemingway Stadium, where Ole Miss Athletics lists the Rebels at No. 9 and Missouri at No. 13.
Availability adds uncertainty
Ole Miss 365 reports that Missouri’s starting quarterback is probable, but running back Ahmad Hardy is out and tight end Brett Norfleet is doubtful. Ole Miss has three offensive linemen listed as out, while tight end Hayden Bradley is questionable. Those absences strengthen Missouri’s case in the rushing matchup, though the Tigers’ own missing contributors limit confidence in the wager.
SportsPicksForum makes Ole Miss a 5.5-point favorite and -225 on the moneyline, with Missouri at +185 and the total at 58.5. Home field makes the Rebels the likelier winner, but the moneyline asks bettors to pay a steep price in a matchup where Missouri can attack Ole Miss’ run defense. The betting lean is Missouri +5.5 at low confidence.
Pick
Ole Miss Rebels
Confidence
low
Betting lean
Missouri Tigers +5.5