NCAAF Predictions

Ohio State Buckeyes vs Indiana Hoosiers Predictions

Saturday, October 17, 2026 at 12:00pm EST

Ohio State

Buckeyes

5-1
Spread -3
@
Indiana

Hoosiers

6-0
Spread +3
50% 50%
Spread Ohio State Buckeyes -3 Indiana Hoosiers +3
Moneyline Ohio State Buckeyes -142 Indiana Hoosiers +120
Total Over 49.5 (-105) Under 49.5 (-115)
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Ohio State vs. Indiana Prediction: Home Streak Makes Buckeyes -3 a Pass

Analysis updated October 17, 2026 at 7:04 AM CDT

The market favors Ohio State in a top-five matchup, but Indiana’s 22-game winning streak makes both Buckeyes prices difficult to justify.

Indiana’s streaks argue against laying 3 points

The Associated Press reports that No. 5 Indiana is 6-0 and has won 22 consecutive games, including 19 straight at home. No. 4 Ohio State enters Bloomington at 5-1 as a 3-point favorite, but Indiana’s record makes that spread difficult to lay without stronger evidence of a matchup advantage.

Ohio State receiver Jeremiah Smith is a Heisman Trophy frontrunner, according to the Associated Press. Indiana counters with Charlie Becker and Nick Marsh, identified by the AP as the nation’s top receiving tandem. Both teams have dangerous targets, so the available evidence doesn’t establish the clear personnel edge needed to back Ohio State -3.

Betting view

The SPF market makes Ohio State the likely winner at -162, with Indiana at +136 and the total at 50.5. There’s no confirmed starter or injury information available, and paying the favorite’s price requires more certainty than the evidence provides. Pass on the moneyline and spread.

Pick Ohio State Buckeyes
Confidence low
Betting lean Pass
Odds and availability can change. Confirm current markets before placing a wager.
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