NCAAF Predictions

Ohio State Buckeyes vs Iowa Hawkeyes Predictions

Saturday, October 3, 2026 at 3:30pm EST at Kinnick Stadium, Iowa City, IA

Ohio State

Buckeyes

Spread -14.5
@
Iowa

Hawkeyes

Spread +14.5
50% 50%
Spread Ohio State Buckeyes -14.5 Iowa Hawkeyes +14.5
Moneyline Ohio State Buckeyes -700 Iowa Hawkeyes +500
Total Over 46.5 (-112) Under 46.5 (-108)
Professional Picks

Professional Picks On This Game

3 listed
Staff Preview

Ohio State vs. Iowa Prediction: Hawkeyes Worth a Look at +14.5

Analysis updated October 3, 2026 at 7:49 AM CDT

Ohio State should win at Kinnick Stadium, but its defensive showing against Illinois makes a 14.5-point spread harder to trust.

Smith tests Iowa's secondary

Jeremiah Smith is the clearest matchup problem for Iowa. CBS Sports reported that the Ohio State receiver had 33 catches for 617 yards and seven touchdowns through four games. The Associated Press noted that he caught four touchdown passes against Illinois and leads the FBS with 154.3 receiving yards per game.

Iowa allowed six Michigan pass plays of at least 20 yards in its last game, according to the Associated Press. That vulnerability gives Ohio State the stronger case to win, and the Buckeyes also won the past two meetings by 44 and 28 points.

The case for Iowa +14.5

The SPF line makes Ohio State a 14.5-point road favorite with a -625 moneyline. That moneyline offers little value, while the spread requires the Buckeyes to win comfortably against an Iowa team that is 4-0 after beating Michigan on the final play.

Ohio State's defense allowed 462 yards and 25 first downs in a 42-19 win over Illinois, CBS Sports reported. Iowa quarterback Hank Brown also led a game-winning drive at Michigan, finishing it with a touchdown pass to Reece Vander Zee. Those results make Iowa +14.5 more attractive than Ohio State at a heavy moneyline price.

No starter or injury information is available, which limits confidence in the wager. Ohio State is the likely winner, but Iowa plus the points is the better lean at the listed prices.

Pick Ohio State Buckeyes
Projected score Ohio State Buckeyes 27, Iowa Hawkeyes 17
Confidence medium
Betting lean Iowa Hawkeyes +14.5
Odds and availability can change. Confirm current markets before placing a wager.
Previous Matchups