Oregon
Ducks
Spread
-3.5
NCAAF Predictions
Oregon Ducks vs USC Trojans Predictions
Saturday, September 26, 2026 at 7:30pm EST at Los Angeles Memorial Coliseum, Los Angeles, CA
@
USC
Trojans
Spread
+3.5
50%
50%
Spread
Oregon Ducks -3.5
USC Trojans +3.5
Moneyline
Oregon Ducks -175
USC Trojans +145
Total
Over 61.5 (-110)
Under 61.5 (-110)
Who wins this game?
Professional Picks
1 available
Professional Picks On This Game
Lane Gibson
Total pick
Oregon vs. USC Prediction: Ducks Favored, but Pass at -3
Analysis updated September 25, 2026 at 8:35 AM CDT
Oregon is favored by 3 points at USC, but the available evidence does not show whether the Ducks justify the road price.
Oregon is favored without enough supporting data
Oregon is a 3-point road favorite at the Los Angeles Memorial Coliseum. The Ducks are -166 on the moneyline, USC is +140, and the total is 61.5.
The price makes Oregon the likely winner, but no verified season statistics, recent results, projected starters or line movement are available to test that assessment. Laying 3 points or paying -166 based only on the market would require more certainty than the evidence provides.
USC has confirmed absences and defensive questions
USC Trojans On SI reports that wide receiver Corey Simms, safety Kendarius Reddick, linebacker Taylor "Taybo" Johnson and offensive lineman Kilian O'Connor are out. Wide receiver Trent Mosley is doubtful, while defensive tackle Jahkeem Stewart, safety Alex Graham and linebacker Jadyn Walker are questionable.
Running back Deshonne Redeaux and linebacker Elijah Newby are probable. USC's unavailable players strengthen the straight-up case for Oregon, but Oregon's own availability is unconfirmed, and the possible USC defensive absences don't establish value on either the spread or the 61.5 total. The bet is a pass.
Pick
Oregon Ducks
Confidence
low
Betting lean
Pass