Notre Dame
Fighting Irish
3-0
Spread
-27.5
NCAAF Predictions
Notre Dame Fighting Irish vs Purdue Boilermakers Predictions
Saturday, September 26, 2026 at 2:00pm EST at Ross-Ade Stadium, West Lafayette, IN
@
Purdue
Boilermakers
1-2
Spread
+27.5
50%
50%
Spread
Notre Dame Fighting Irish -27.5
Purdue Boilermakers +27.5
Moneyline
Notre Dame Fighting Irish -4500
Purdue Boilermakers +1700
Total
Over 57.5 (-105)
Under 57.5 (-115)
Who wins this game?
Professional Picks
1 available
Professional Picks On This Game
Casper Kohke
Spread pick
Notre Dame vs. Purdue Prediction: Irish Favored, but 27.5-Point Spread Is a Pass
Analysis updated September 26, 2026 at 7:21 AM CDT
Notre Dame enters 3-0, while Purdue’s weak run defense favors the Irish. The available evidence does not support a wager at the SPF price.
Notre Dame has the clearer path to a win
NBC Sports reports that Notre Dame enters Saturday’s game at Purdue with a 3-0 record after beating Michigan State 27-10. CJ Carr completed 75% of his passes for 234 yards and ran for a touchdown in that victory, supporting Notre Dame as the likely winner.
Purdue is allowing 207 rushing yards per game, the highest figure in the Big Ten, according to NBC Sports. Notre Dame has averaged only 130.0 rushing yards through three games, but Purdue’s defensive record still gives the Irish a favorable matchup.
Why the spread is a pass
Purdue quarterback Ryan Browne threw for a career-high 378 yards and three touchdowns against UCLA, but the Boilermakers lost 52-38. That performance shows some scoring potential, though one productive game does not establish that Purdue can cover against Notre Dame.
SPF lists Notre Dame at -27.5 and -4500 on the moneyline. The moneyline offers little return, while the available evidence does not justify laying 27.5 points or backing Purdue solely because the spread is large. Pass on the wager.
Pick
Notre Dame Fighting Irish
Confidence
low
Betting lean
Pass