Iowa
Hawkeyes
Spread
+5.5
NCAAF Predictions
Iowa Hawkeyes vs Michigan Wolverines Predictions
Saturday, September 26, 2026 at 3:30pm EST at Michigan Stadium, Ann Arbor, MI
@
Michigan
Wolverines
Spread
-5.5
50%
50%
Spread
Iowa Hawkeyes +5.5
Michigan Wolverines -5.5
Moneyline
Iowa Hawkeyes +180
Michigan Wolverines -218
Total
Over 38.5 (-112)
Under 38.5 (-108)
Who wins this game?
Professional Picks
3 available
Professional Picks On This Game
Iowa vs. Michigan Prediction: Wolverines Favored, but Pass at -218
Analysis updated September 26, 2026 at 7:59 AM CDT
Iowa’s efficient rushing attack and strong run defense support a cautious approach, while quarterback Hank Brown faces his first road start.
Iowa’s running game could keep it close
Michigan is favored by 5.5 points and priced at -218 on the moneyline, but Iowa has the running game to challenge both numbers. Maize n Brew, a Michigan sports publication, reports that the Hawkeyes are averaging 7.4 yards per carry and have scored nine rushing touchdowns this season.
Iowa has also held opponents to 198 rushing yards and 2.2 yards per carry. Without Michigan season statistics or confirmed lineup information for comparison, Iowa’s run defense makes laying 5.5 points with the Wolverines a difficult bet.
Brown’s road test favors Michigan
Iowa quarterback Hank Brown has completed 45 of 62 passes for 473 yards and three touchdowns, according to Maize n Brew. This will be his first road start, which gives Michigan the stronger case to win at home but doesn’t justify paying -218.
The total is 38.5, but no weather, availability, recent-results or pace data is available to evaluate it. The reported 50-50 moneyline split is a default figure rather than measured betting activity, so it doesn’t support a wager. Michigan is the likely winner, but the betting lean is Pass.
Pick
Michigan Wolverines
Confidence
low
Betting lean
Pass