Arizona
Cardinals
Spread
+12.5
NFL Predictions
Arizona Cardinals vs Los Angeles Rams Predictions
Sunday, October 18, 2026 at 4:05pm EST at SoFi Stadium, Inglewood, CA
@
Los Angeles
Rams
Spread
-12.5
50%
50%
Spread
Arizona Cardinals +12.5
Los Angeles Rams -12.5
Moneyline
Arizona Cardinals +500
Los Angeles Rams -700
Total
Over 51.5 (-105)
Under 51.5 (-115)
Professional Picks
8 listed
Professional Picks On This Game
Tom Strickland
Spread pick
Simon Says
Total pick
Elijah Murtah
Total pick
Casper Kohke
Spread pick
Scott Steele
Total pick
Percy Walker
Spread pick
Percy Walker
Total pick
Bryan Pratt
Total pick
Cardinals vs. Rams Prediction: Los Angeles Is Likely to Win, but Pass at -800
Analysis updated October 18, 2026 at 7:18 AM CDT
Arizona's absences favor Los Angeles, but the Rams' -800 moneyline and 12.5-point spread require more confidence than the available matchup evidence supports.
Arizona's Absences Favor the Rams
The Rams are 12.5-point home favorites, and Arizona enters without running back Jeremiyah Love because of an ankle injury. The Arizona Cardinals report that Tyler Allgeier is expected to become the team's lead back.
Arizona will also be without safeties Wydett Williams and Dewey Wingard. Those absences could be important against a Los Angeles offense that leads the NFL by using three-tight-end personnel on 30.8% of its snaps, according to the Arizona Cardinals.
The Price Is Too Steep
Rams linebacker Nate Landman forced two fumbles against Buffalo in Week 5. He is tied for the NFL lead with 10 forced fumbles since 2024, giving Los Angeles a proven source of takeaways.
Los Angeles is the likely winner, but the Rams' -800 moneyline offers little return and the evidence does not support laying 12.5 points. Team records, confirmed starters and recent results are unavailable, so there is no reliable basis for a projected score. The 51.5 total also lacks enough support for an over or under bet. Pass.
Pick
Los Angeles Rams
Confidence
low
Betting lean
Pass