Indianapolis
Colts
Spread
+3
NFL Predictions
Indianapolis Colts vs Pittsburgh Steelers Predictions
Sunday, October 11, 2026 at 1:00pm EST at Acrisure Stadium, Pittsburgh, PA
@
Pittsburgh
Steelers
Spread
-3
50%
50%
Spread
Indianapolis Colts +3
Pittsburgh Steelers -3
Moneyline
Indianapolis Colts +136
Pittsburgh Steelers -162
Total
Over 41.5 (-110)
Under 41.5 (-110)
Professional Picks
8 listed
Professional Picks On This Game
Simon Says
Spread pick
Elijah Murtah
Spread pick
Oliver Peters
Total pick
Primetime Ryan Johnson
Total pick
Scott Steele
Total pick
Eli Rothstein
Total pick
Bryan Pratt
Spread pick
Chris Cohen
Spread pick
Colts vs. Steelers Prediction: Pittsburgh Favored, but Pass at This Price
Analysis updated October 11, 2026 at 7:12 AM CDT
The Steelers are the likelier winner at home, but the available evidence does not justify laying -148 or 2.5 points.
Prediction
Pittsburgh is the likelier winner Sunday at Acrisure Stadium, but neither Steelers price offers a clear betting edge. SPF lists Pittsburgh at -148 on the moneyline and -2.5 against the spread, with too little confirmed performance and lineup information to justify either wager.
Colts.com reports that Indianapolis enters the game after beating Washington 30-13 in London. Jonathan Taylor carried 20 times for 95 yards and two touchdowns, giving the Colts one recent source of proven production. The team also placed defensive end Arden Key on injured reserve after he started each of its first four games, weakening Indianapolis' available pass-rush depth.
Roster changes leave important questions
Steelers.com reports that Pittsburgh placed wide receiver Michael Pittman Jr. on the Reserve/Injured List after he started three games this season. Pittsburgh elevated running back Lew Nichols and wide receiver Brandon Smith, while Indianapolis elevated wide receiver Nick Westbrook-Ikhine.
Those moves affect both teams, but the available information does not establish how the replacements will change either offense. That uncertainty also leaves no sound case for the total of 43.5, priced at -108 on the over and -112 on the under. The best betting decision is to pass on the side and total.
Pick
Pittsburgh Steelers
Confidence
low
Betting lean
Pass