Detroit Lions vs Arizona Cardinals Predictions

Arizona’s offensive line faces Detroit’s pressure

Detroit enters with 15 sacks, second most in the NFL, and 99 pressures, third most, according to the Detroit Lions. Arizona’s offensive line will start Jon Gaines II for right guard Isaiah Adams, who was placed on injured reserve with an ankle injury. Rookie Jayden Williams has also replaced injured left tackle Paris Johnson Jr.

That matchup favors Detroit against Jacoby Brissett, who has been sacked seven times in four games. The Arizona Cardinals also expect wide receiver Marvin Harrison Jr. to be a healthy inactive, leaving Brissett without one potential target.

Detroit’s offense strengthens the case for an outright win. The Lions are averaging 29.8 points and 389.3 yards per game, while Jared Goff has completed 67.7% of his passes for 1,214 yards, nine touchdowns and no interceptions.

The prices do not offer a strong bet

The SPF moneyline asks bettors to risk $250 to win $100 on Detroit. The matchup points toward the Lions, but the available evidence does not justify that cost.

Detroit is also favored by 5.5 points, and the total is 54.5. There is not enough information about the teams’ overall performance to support either market, so the betting lean is Pass.