Arizona
Diamondbacks
82-74
Moneyline
-181
MLB Predictions
Arizona Diamondbacks vs Colorado Rockies Predictions
Tuesday, September 22, 2026 at 8:40pm EST
@
Colorado
Rockies
57-99
Moneyline
+149
50%
50%
Spread
Arizona Diamondbacks -1.5
Colorado Rockies +1.5
Moneyline
Arizona Diamondbacks -181
Colorado Rockies +149
Total
Over 11 (-105)
Under 11 (-115)
Professional Picks
3 listed
Professional Picks On This Game
Diamondbacks vs. Rockies Prediction: Soroka Gives Arizona the Edge at -198
Analysis updated September 22, 2026 at 5:22 AM CDT
Arizona has the stronger probable starter. That makes the Diamondbacks the winner pick, but doesn't establish value at SPF's moneyline price.
Soroka's pitching edge comes at a cost
Michael Soroka's 3.45 ERA and 1.13 WHIP compare favorably with Kyle Freeland's 6.38 ERA and 1.47 WHIP. ESPN / Data Skrive lists both as probable starters for Tuesday's series opener in Denver. That matchup favors Arizona, which SPF prices at -198 against Colorado at +163.
At -198, Arizona needs to win about 66.4% of the time to break even. ESPN / Data Skrive reports that the Diamondbacks are 82-74 overall but 37-38 on the road. The pitching comparison supports picking Arizona to win; those records don't establish that it clears the betting threshold.
Colorado's bats leave the total unresolved
The same preview ranks Colorado fourth in MLB with a .416 slugging percentage. That extra-base ability gives Soroka a meaningful test, though it doesn't by itself justify backing the Rockies or betting over SPF's total of 11.
SPF lists over 11 at -105 and under 11 at -115. With starters still probable and no confirmed lineups or weather information, there's no supported total wager. The listed Arizona -1.5 run line also lacks a price to evaluate. Betting lean: Pass.
Pick
Arizona Diamondbacks
Confidence
medium
Betting lean
Pass