San Diego
Padres
38-40
Moneyline
+109
MLB Predictions
San Diego Padres vs Los Angeles Dodgers Predictions
Tuesday, September 22, 2026 at 10:10pm EST
@
Los Angeles
Dodgers
Moneyline
-131
50%
50%
Spread
San Diego Padres +1.5
Los Angeles Dodgers -1.5
Moneyline
San Diego Padres +109
Los Angeles Dodgers -131
Total
Over 8.5 (-103)
Under 8.5 (-117)
Professional Picks
2 listed
Professional Picks On This Game
Jonah Black
Money pick
Matt O'Brien
Total pick
Padres vs. Dodgers Prediction: Yamamoto Gives Los Angeles the Edge
Analysis updated September 22, 2026 at 5:28 AM CDT
Los Angeles is the winner pick at home. The case for a wager is weaker against a Padres team batting .321 over its past 10 games.
Yamamoto leads the case for Los Angeles
Yoshinobu Yamamoto gives the Dodgers a starting-pitching edge at SPF's -120 moneyline. Yahoo Sports / Associated Press lists him as the probable starter with a 2.51 ERA and 0.87 WHIP, compared with Michael King's 3.03 ERA and 1.16 WHIP for San Diego. Neither starter is confirmed.
Los Angeles is the winner pick, with its 50-28 home record adding to the case. The Padres are 38-40 on the road, and the Dodgers lead the season series 7-3.
Betting decision: Pass
San Diego has gone 9-1 with a .321 batting average over its past 10 games, according to the same report. That gives Yamamoto a difficult assignment, while Shohei Ohtani's absence on the injured list with a biceps injury removes a key bat from Los Angeles' lineup. At -120, the Dodgers need to win more than 54.5% of the time to break even; the evidence doesn't establish that betting edge.
The Padres' +100 price isn't an automatic alternative. Their 4.70 ERA over that stretch and shoulder injuries sidelining relievers Jeremiah Estrada and Jason Adam weaken the pitching case. Those concerns also make an under bet difficult to justify solely from the probable starters. Pass on the moneyline and SPF's total of 8.
Pick
Los Angeles Dodgers
Confidence
low
Betting lean
Pass