St. Louis
Cardinals
Moneyline
+140
MLB Predictions
St. Louis Cardinals vs Pittsburgh Pirates Predictions
Tuesday, September 22, 2026 at 6:40pm EST
@
Pittsburgh
Pirates
Moneyline
-169
50%
50%
Spread
St. Louis Cardinals +1.5
Pittsburgh Pirates -1.5
Moneyline
St. Louis Cardinals +140
Pittsburgh Pirates -169
Total
Over 7 (-115)
Under 7 (-104)
Professional Picks
3 listed
Professional Picks On This Game
Cardinals vs. Pirates prediction: Pittsburgh is the likelier winner, but the price is high
Analysis updated September 22, 2026 at 6:00 AM CDT
SportsPicksForum lists Pittsburgh at -155 and St. Louis at +128 with a total of 7. FantasyTeamAdvice’s live scoreboard points to Andre Pallante and Jared Jones as the probable starters, but the lack of confirmed lineups or recent form keeps the bet tied to price.
Market setup
SportsPicksForum has Pittsburgh as the home favorite at -155, with St. Louis at +128 and the total at 7. That is a short number, which usually signals a close game.
A low total leaves less room for a favorite to separate. Pittsburgh can still win, but the moneyline asks you to pay for that edge up front.
What the lineup note adds
FantasyTeamAdvice, a live MLB scoreboard page, lists Andre Pallante for St. Louis and Jared Jones for Pittsburgh as the probable starters. It also shows the game at 6:40 p.m. with the same tight scoring range.
That is useful, but it is still only a probable-starting-pitcher listing. There are no confirmed lineups, no validated injuries, and no recent form or season-stat edge in the research, so the handicap stays shallow.
Betting take
The best read is Pittsburgh to win, but St. Louis +128 is the better wager because the price is easier to justify in a game lined at 7. If the Pirates do get home, a tight result is still the most likely path, and that makes the underdog moneyline more attractive than laying -155.
The Cardinals +1.5 is also playable on the same logic, but the cleaner lean is the plus-money moneyline. With the information on hand, Pass on the total.
Pick
Pittsburgh Pirates
Confidence
low
Betting lean
St. Louis Cardinals moneyline +128