MLB Predictions

Washington Nationals vs Detroit Tigers Predictions

Tuesday, September 22, 2026 at 6:40pm EST at Comerica Park, Detroit, Michigan

Washington

Nationals

Moneyline +129
@
Detroit

Tigers

Moneyline -156
50% 50%
Spread Washington Nationals +1.5 Detroit Tigers -1.5
Moneyline Washington Nationals +129 Detroit Tigers -156
Total Over 8 (-116) Under 8 (-104)

Who wins this game?

Professional Picks

Professional Picks On This Game

3 available
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Tigers vs. Nationals Prediction: Anderson’s ERA Edge Meets a -156 Price

Analysis updated September 21, 2026 at 11:07 PM CDT

Detroit is the winner pick behind scheduled starter Drew Anderson. Whether that edge justifies the price is less clear.

Pitching matchup and betting value

Detroit’s scheduled starter Drew Anderson brings a 3.62 ERA into Tuesday’s matchup against Washington left-hander Jackson Kent, who has a 6.40 ERA, according to CBS Sports / Associated Press. That ERA gap makes the Tigers the tentative winner pick, but SPF’s -156 moneyline requires a win probability of about 60.9% to break even. ERA alone doesn’t establish that they clear that threshold.

Nationals Roundtable, a Washington-focused baseball outlet, reports that Detroit won Monday’s opener 9-2 and held the Nationals to five hits. That result adds recent context, but it offers little basis for pricing a game with different scheduled starters.

Washington is +129 at SPF, and the total is 8, with the over at -116 and under at -104. Without confirmed lineups or enough information about bullpen availability, neither the underdog price nor the total supports a wager. The betting recommendation is Pass.

Pick Detroit Tigers
Confidence low
Betting lean Pass
Odds and availability can change. Confirm current markets before placing a wager.
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