Tampa Bay
Rays
19-7
Moneyline
+124
MLB Predictions
Tampa Bay Rays vs New York Yankees Predictions
Tuesday, September 22, 2026 at 1:05pm EST
@
New York
Yankees
Moneyline
-149
23%
77%
Spread
Tampa Bay Rays +1.5
New York Yankees -1.5
Moneyline
Tampa Bay Rays +124
New York Yankees -149
Total
Over 6.5 (-120)
Under 6.5 (+100)
Professional Picks
5 listed
Professional Picks On This Game
Rich Roth
Money pick
Rich Roth
Total pick
Kit Wilson
Money pick
Garrett Perry
Money pick
Simon Says
Money pick
Rays vs. Yankees Prediction: Tampa Bay at +105 in Opener
Analysis updated September 22, 2026 at 5:02 AM CDT
Similar pitching numbers make Tampa Bay’s recent results and New York’s missing slugger the main reasons to lean toward the underdog.
Why Tampa Bay gets the lean
With the scheduled starters carrying nearly identical ERAs, Tampa Bay’s 19-7 record since Aug. 23 gives the Rays a modest appeal at SPF’s +105 against the Yankees at -126. Yardbarker (syndicated from Field Level Media), carrying the sports news service’s preview, reports that Tampa Bay also won six of the teams’ first nine meetings this season.
The same report places Aaron Judge on the injured list with a strained calf. His absence weakens New York’s batting options and adds to the case for a small Rays moneyline lean, though confirmed batting orders aren’t available.
Rodón keeps this a close call
Sports publication Heavy lists Nick Martinez against Carlos Rodón for the September 22 opener at 1:05 p.m. EDT at Yankee Stadium. Martinez enters with a 2.94 ERA, compared with Rodón’s 2.95, according to the syndicated preview. Their recent numbers are similarly close: Martinez has a 2.43 ERA over five starts, while Rodón has a 2.40 ERA in six starts since returning from the injured list.
Those results give New York a credible chance and limit confidence in the pick. They also make SPF’s total of seven tempting to play under, but without confirmed lineups or bullpen availability, the total is a pass.
Pick
Tampa Bay Rays
Confidence
low
Betting lean
Tampa Bay Rays moneyline +105