Los Angeles
Rams
Spread
-2.5
NFL Predictions
Los Angeles Rams vs Denver Broncos Predictions
Sunday, September 27, 2026 at 8:20pm EST at Empower Field at Mile High, Denver, CO
@
Denver
Broncos
Spread
+2.5
50%
50%
Spread
Los Angeles Rams -2.5
Denver Broncos +2.5
Moneyline
Los Angeles Rams -130
Denver Broncos +110
Total
Over 43.5 (-118)
Under 43.5 (-102)
Who wins this game?
Professional Picks
5 available
Professional Picks On This Game
Wes Salvato
Spread pick
Elijah Murtah
Spread pick
Oliver Peters
Spread pick
Scott Steele
Spread pick
Chris Cohen
Total pick
Rams vs. Broncos prediction: Los Angeles is the likelier winner, but Puka Nacua’s doubtful tag makes the price hard to love
Analysis updated September 26, 2026 at 6:10 AM CDT
Los Angeles is still the side the market prefers, yet a -130 moneyline and -2.5 spread leave little margin after the Puka Nacua injury news, so this looks more like a pass than a wager.
Market read
SPF lists the Rams at -130 on the moneyline and -2.5 on the spread, with Denver at +110 and +2.5. That tells you Los Angeles is expected to win, but not by much. The total is 44.5, which points to a game with limited scoring room and makes every absent playmaker matter more.
Key availability note
NFL.com reported that Puka Nacua is doubtful for Sunday night after missing practice all week with a hip injury. That is the cleanest verified game note in the research and it matters for the Rams because it can cut into their passing game. With Los Angeles already laying a short road number, that injury pushes the price closer to the edge.
Betting angle
The Rams are still the more likely winner, but the bet is not attractive at this number. A road favorite at -130 has to do enough to justify the juice, and the -2.5 spread does not give much cushion if the offense is missing Nacua. Denver at +110 is the side that would benefit if this stays tight, but the verified data does not go far enough to call that a value play.
Bottom line
Los Angeles should be the safer pick to win outright, but the spread and moneyline are short enough that the better betting answer is Pass.
Pick
Los Angeles Rams
Projected score
Rams 23, Broncos 20
Confidence
low
Betting lean
pass