Tennessee
Titans
Spread
+2.5
NFL Predictions
Tennessee Titans vs New York Giants Predictions
Sunday, September 27, 2026 at 1:00pm EST
@
New York
Giants
Spread
-2.5
50%
50%
Spread
Tennessee Titans +2.5
New York Giants -2.5
Moneyline
Tennessee Titans +110
New York Giants -130
Total
Over 37.5 (-112)
Under 37.5 (-108)
Professional Picks
4 listed
Professional Picks On This Game
Abe Howland
Total pick
Don Williams
Spread pick
Simon Says
Spread pick
Bryan Pratt
Spread pick
Titans vs. Giants Prediction: Injuries Make New York -2.5 a Pass
Analysis updated September 27, 2026 at 7:13 AM CDT
New York is favored with Jameis Winston slated to start, while both teams have important players listed as questionable.
New York's protection is intact, but its defense may not be
NBC Sports / Pro Football Talk reports that Jameis Winston is slated to start for New York, with Jake Haener as his backup. The New York Giants also report that offensive tackle Andrew Thomas has no injury designation, giving Winston his starting left tackle against Tennessee.
The Giants list outside linebacker Brian Burns, cornerback Deonte Banks and safety Tyler Nubin as questionable. Those potential absences make New York difficult to back at -2.5, even as the home favorite.
Tennessee's backfield remains unsettled
Titans running back Tyjae Spears is questionable with an ankle injury. NBC Sports / Pro Football Talk reports that Tennessee elevated Michael Carter for this game, while Tony Pollard has no injury designation after an ankle issue placed him on the injury report. Cornerback Cor'Dale Flott is also questionable.
SPF lists the Giants at -130 on the moneyline and -2.5 against the spread, with a total of 37.5. New York is the more likely winner based on those prices, but the available evidence doesn't establish a matchup edge worth betting. Pass on the side and total.
Pick
New York Giants
Confidence
low
Betting lean
Pass