NCAAF Predictions

Tulane Green Wave vs Duke Blue Devils Predictions

Saturday, September 5, 2026 at 3:30pm EST at Wallace Wade Stadium, Durham, NC

Tulane

Green Wave

Spread +9.5
@
Duke

Blue Devils

Spread -9.5
50% 50%
Spread Tulane Green Wave +9.5 Duke Blue Devils -9.5
Moneyline Tulane Green Wave +275 Duke Blue Devils -345
Total Over 52.5 (-105) Under 52.5 (-115)

Who wins this game?

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Tulane at Duke Prediction: Blue Devils to Win, Pass at -345

Analysis updated September 5, 2026 at 1:12 AM CDT

Duke gets the nod on prior-season offensive production. Backing the Blue Devils at -345 is a separate call, and the price is too steep with so much still unknown.

Duke gets the edge

Duke is the pick to win Saturday’s opener against Tulane. At -345 on the moneyline and -9.5 against the spread, though, the Blue Devils are a pass. Tulane is +275 to win outright and +9.5, with the total at 52.5.

Both teams enter 0-0. Duke’s game center lists prior-season leaders Darian Mensah with 3,973 passing yards, Nate Sheppard with 1,132 rushing yards and Cooper Barkate with 1,106 receiving yards. That production gives Duke the edge in this forecast, but it does not establish the lineup or how the offense will perform in the opener.

Tulane’s listed leaders include Jake Retzlaff with 3,168 passing yards and a team-high 634 rushing yards, plus Shazz Preston with 723 receiving yards. Retzlaff’s production through the air and on the ground is the strongest reason to hesitate before laying 9.5 points with Duke.

The price keeps this a pass

No verified current injury report or starting lineup is available. Recent results, team-wide season statistics and line movement are also unavailable, leaving little basis to judge current form or availability.

Duke is the likelier winner, but the available information does not justify paying -345. Tulane’s prior-season quarterback production makes the spread difficult to endorse, too, without establishing an edge on the underdog. The prediction is Duke 31-24, with low confidence. Pass on the side.

Pick Duke Blue Devils
Projected score 31-24
Confidence low
Betting lean Pass
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Previous Matchups
9/5