MLB Predictions

St. Louis Cardinals vs Milwaukee Brewers Predictions

Sunday, September 27, 2026 at 3:10pm EST at American Family Field, Milwaukee, Wisconsin

St. Louis

Cardinals

Moneyline +178
@
Milwaukee

Brewers

Moneyline -218
50% 50%
Spread St. Louis Cardinals +1.5 Milwaukee Brewers -1.5
Moneyline St. Louis Cardinals +178 Milwaukee Brewers -218
Total Over 7 (-119) Under 7 (-101)
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Cardinals vs. Brewers Prediction: Milwaukee Is Likely, but -250 Is Too Steep

Analysis updated September 27, 2026 at 7:33 AM CDT

Milwaukee has the stronger listed starter in the regular-season finale, but that advantage doesn't justify betting the Brewers at -250.

Misiorowski gives Milwaukee the pitching edge

WRAL / Associated Press lists Milwaukee's Jacob Misiorowski at 15-5 with a 1.86 ERA and St. Louis starter Andre Pallante at 12-8 with a 3.61 ERA. That gap makes the Brewers the more likely winner, but a -250 moneyline leaves little room for uncertainty.

Milwaukee earned its major league-leading 102nd win by beating St. Louis 3-2 on Saturday. The close result doesn't predict Sunday's margin, but it offers no added reason to pay a heavy favorite's price or back Milwaukee -1.5 without an available run-line price.

Cardinals lose Winn for the finale

WRAL / Associated Press reports that Cardinals shortstop Masyn Winn won't play Sunday after he was scratched with left thumb and hand soreness. Brewers infielder Joey Ortiz had an MRI after dealing with right knee, oblique and groin issues, but his availability wasn't established.

Winn's absence adds to Milwaukee's case as the likely winner. It still doesn't make the -250 moneyline attractive. The total is 7, with the under priced at -118 and the over at -102, but the available evidence doesn't support a total wager. Pass.

Pick Milwaukee Brewers
Confidence low
Betting lean Pass
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