MLB Predictions

Pittsburgh Pirates vs Chicago Cubs Predictions

Saturday, September 12, 2026 at 2:20pm EST at Wrigley Field, Chicago, Illinois

Pittsburgh

Pirates

Moneyline +104
@
Chicago

Cubs

Moneyline -126
44% 56%
Spread Pittsburgh Pirates Chicago Cubs
Moneyline Pittsburgh Pirates +104 Chicago Cubs -126
Total None

Who wins this game?

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Staff Preview

Pirates at Cubs Prediction: Holmes’ ERA Edge Meets a -126 Price

Analysis updated September 12, 2026 at 5:25 AM CDT

Holmes has the lower ERA entering the probable pitching matchup with Paul Skenes. Chicago gets a low-confidence winner lean; the moneyline is a pass.

The case for Chicago

Clay Holmes’ 2.83 ERA gives Chicago an edge over Paul Skenes’ 3.83 in Saturday’s probable pitching matchup. FanDuel Research, FanDuel’s sports analysis publication, lists both right-handers as probable starters. SPF prices the Cubs at -126 and the Pirates at +104.

The same preview lists Chicago at 82-66 and Pittsburgh at 74-74 entering the 2:20 p.m. ET game at Wrigley Field. The better record and lower starter ERA favor the Cubs as a tentative winner pick, though neither measures their chances precisely enough to establish betting value.

Betting decision

At -126, Chicago needs to win about 55.8% of the time to break even. Without confirmed starters and lineups or details on bullpen availability, there's too little to judge whether the Cubs clear that threshold. Pass on the moneyline. SPF's run-line and total prices are unavailable, so those markets are also passes.

Pick Chicago Cubs
Confidence low
Betting lean Pass
Odds and availability can change. Confirm current markets before placing a wager.
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