Southern
Jaguars
Spread
+35.5
NCAAB Predictions
Southern Jaguars vs Iowa State Cyclones Predictions
Tuesday, November 10, 2026 at 8:00pm EST
@
Iowa State
Cyclones
Spread
-35.5
50%
50%
Spread
Southern Jaguars +35.5
Iowa State Cyclones -35.5
Moneyline
Southern Jaguars
Iowa State Cyclones
Total
Over 146.5 (-105)
Under 146.5 (-115)
Who wins this game?
Professional Picks
1 available
Professional Picks On This Game
Matt O'Brien
Spread pick
Southern at Iowa State prediction: Cyclones are the likelier winner, but -35.5 is a big ask
Analysis updated November 10, 2026 at 6:02 AM CST
SPF lists Iowa State as a 35.5-point favorite with the total at 147.5 for Tuesday’s game in Ames. The Cyclones should win at home, but the number leaves the spread in pass territory.
Matchup outlook
SPF’s authoritative price has Southern at +35.5, Iowa State at -35.5, and the total at 147.5.
Iowa State should control the game at Hilton Coliseum, but a 35.5-point spread leaves very little room for a late empty stretch or a deep bench rotation to ruin a cover. That is the main betting issue here: the Cyclones look like the better team, yet the line asks for a runaway margin.
What the market says
SPF does not list a moneyline, so the spread is the cleanest market signal available.
That pushes the bet choice toward restraint. Iowa State is the more likely winner, but a number this large needs a strong case for pace, depth, or mismatches, and the available market data does not give that kind of edge.
Availability and context
The available game notes confirm the matchup in Ames, but there are no verified injuries or starter updates in the odds source to sharpen the handicap.
Without confirmed lineup news or trustworthy recent-form data tied to the SPF price, it is safer to separate the likely winner from the wager. Iowa State can win comfortably and still fall short of a cover this large.
Prediction
Iowa State is the likely winner, but the spread is too steep to back the Cyclones.
Pass on the side.
Pick
Iowa State Cyclones
Confidence
low
Betting lean
Pass