Los Angeles
Chargers
Spread
+7
NFL Predictions
Los Angeles Chargers vs Seattle Seahawks Predictions
Sunday, October 4, 2026 at 4:25pm EST at Lumen Field, Seattle, WA
@
Seattle
Seahawks
Spread
-7
50%
50%
Spread
Los Angeles Chargers +7
Seattle Seahawks -7
Moneyline
Los Angeles Chargers +275
Seattle Seahawks -345
Total
Over 43.5 (-110)
Under 43.5 (-110)
Who wins this game?
Professional Picks
4 listed
Professional Picks On This Game
Don Williams
Total pick
Simon Says
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King Jon Sanderson
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Lane Gibson
Total pick
Chargers vs. Seahawks Prediction: Seattle Favored, but Pass at -375
Analysis updated October 4, 2026 at 7:25 AM CDT
The SPF market makes Seattle the likely winner, though the price and limited matchup evidence leave no worthwhile bet.
Seattle's price requires more evidence
Seattle is a 7-point home favorite and -375 on the moneyline, with Los Angeles at +7 and +295. Those prices make the Seahawks the straight-up pick, but neither laying seven points nor risking $375 to win $100 is justified without confirmed starters, current form or team performance data.
The total is 42.5, with the over at -118 and the under at -102. Without game-specific offensive, defensive or weather information, there is no sound basis for choosing either side of that number.
Roster moves don't create a betting edge
The Seattle Seahawks reported that rookie running back Jadarian Price went on injured reserve after aggravating a chest injury in practice. Seattle signed running back Velus Jones Jr. and elevated cornerback Trevon Diggs and safety Maxen Hook, but the available information does not show how those moves should affect the seven-point spread.
The Los Angeles Chargers elevated tight end Patrick Herbert and outside linebacker Caleb Murphy from the practice squad. Both were also elevated for Week 3 at Buffalo, so those transactions alone do not support betting Los Angeles or changing the expected winner.
Pick
Seattle Seahawks
Confidence
low
Betting lean
Pass