NFL Predictions

New England Patriots vs Buffalo Bills Predictions

Sunday, October 4, 2026 at 1:00pm EST at Highmark Stadium, Orchard Park, NY

New England

Patriots

1-2
Spread +7
@
Buffalo

Bills

3-0
Spread -7
7% 93%
Spread New England Patriots +7 Buffalo Bills -7
Moneyline New England Patriots +275 Buffalo Bills -345
Total Over 49.5 (-108) Under 49.5 (-112)

Who wins this game?

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Patriots vs. Bills Prediction: Buffalo’s Offense Points to Bills -7

Analysis updated October 4, 2026 at 7:12 AM CDT

The unbeaten Bills average 33.7 points per game, while the Patriots have scored 16 points across two road losses and will be without three defenders.

Buffalo’s offense has a clear edge

Sports Betting Dime, a sports betting news site, reports that Buffalo is 3-0 and averaging 33.7 points and 417.0 yards per game. The Bills have converted 54.5% of their third downs and scored touchdowns on 9 of 12 red-zone trips. New England is 1-2, averages 12.0 points and has been outscored 48-16 in two road games.

The Patriots have also committed eight turnovers and scored one touchdown in six red-zone trips. Those mistakes give Buffalo a strong chance to win and cover the SportsPicksForum spread of seven points.

Patriots face key absences

The New England Patriots announced that cornerbacks Christian Gonzalez and Channing Canada and defensive tackle Christian Barmore are out. Six other players traveled with questionable designations, including right tackle Morgan Moses, but the team noted that traveling doesn’t guarantee they’ll play. The confirmed defensive absences make it harder for New England to slow Buffalo’s efficient attack.

Betting outlook

Buffalo is -298 on the SportsPicksForum moneyline, a steep price despite the matchup advantage. Bills -7 is the better option because it offers more value if Buffalo’s scoring edge produces a comfortable win.

Sports Betting Dime reports that Buffalo has attracted 66.3% of spread tickets and 76.4% of spread money. That support doesn’t strengthen the matchup case by itself, but it shows bettors are already paying a premium to back the favorite.

Pick Buffalo Bills
Projected score Bills 30, Patriots 13
Confidence medium
Betting lean Bills -7
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