Arizona
Diamondbacks
85-74
Moneyline
+111
MLB Predictions
Arizona Diamondbacks vs San Diego Padres Predictions
Friday, September 25, 2026 at 9:40pm EST at Petco Park, San Diego, California
@
San Diego
Padres
89-70
Moneyline
-133
50%
50%
Spread
Arizona Diamondbacks +1.5
San Diego Padres -1.5
Moneyline
Arizona Diamondbacks +111
San Diego Padres -133
Total
Over 7.5 (-112)
Under 7.5 (-107)
Professional Picks
0 listed
Professional Picks On This Game
No professional picks are available for this matchup.
Diamondbacks vs. Padres Prediction: San Diego Favored in Close Matchup
Analysis updated September 25, 2026 at 7:29 AM CDT
San Diego's 49-29 home record makes it the likelier winner, but Arizona's five-game winning streak and the tied season series make -137 difficult to back.
Why San Diego is favored
The Padres enter Friday's game at 89-70, including 49-29 at home, according to AOL / Associated Press. Arizona is 85-74 and 40-38 on the road. Those records favor San Diego, but the Diamondbacks have won five straight and split the first 10 games of the season series. That makes the Padres' -137 moneyline too expensive.
Probable starters
AOL / Associated Press lists Arizona right-hander Brandon Pfaadt and San Diego right-hander Casey Mize as the probable starters. Pfaadt is 7-3 with a 3.72 ERA and 1.17 WHIP. Mize is 6-9 with a 3.96 ERA and 1.19 WHIP. Those numbers don't show a large enough pitching advantage to strengthen the case for laying -137 with San Diego.
Betting prediction
San Diego is the likely winner, but the moneyline is a pass. The total is 7, with the over priced at -124 and the under at +103. Without reliable offensive, bullpen, weather or lineup information, neither side of the total is supportable.
Pick
San Diego Padres
Confidence
low
Betting lean
Pass