Seattle
Seahawks
Spread
-3.5
NFL Predictions
Seattle Seahawks vs Arizona Cardinals Predictions
Sunday, September 20, 2026 at 4:25pm EST at State Farm Stadium, Glendale, AZ
@
Arizona
Cardinals
Spread
+3.5
50%
50%
Spread
Seattle Seahawks -3.5
Arizona Cardinals +3.5
Moneyline
Seattle Seahawks -205
Arizona Cardinals +170
Total
Over 40.5 (-115)
Under 40.5 (-105)
Who wins this game?
Professional Picks
3 available
Professional Picks On This Game
Seahawks at Cardinals Prediction: Drew Lock Starts With Seattle Favored by 3.5
Analysis updated September 19, 2026 at 1:04 AM CDT
Lock's productive relief outing gives Seattle reason for optimism, but it doesn't establish a betting edge at SPF's -218 moneyline.
Lock faces a higher bar as the starter
Drew Lock takes over for injured Sam Darnold with Seattle a 3.5-point road favorite at Arizona on September 20. NFL.com reports that Lock completed 16 of 22 passes for 187 yards and a touchdown in Seattle's 13-10 win over New England. That was a productive relief appearance, but covering SPF's spread requires a win by at least four points.
At -218, Seattle's moneyline requires a win probability above roughly 68.6% to break even. One relief outing doesn't establish that probability. Seattle is the tentative winner pick, with low confidence; the wager is Pass.
Injuries affect both sides of the passing matchup
NFL.com's injury report lists Arizona cornerback Garrett Williams as out with an Achilles injury, with cornerback Max Melton and safety Dadrion Taylor-Demerson questionable. Those absences could give Lock more favorable matchups, but the questionable players aren't confirmed out.
Seattle also has a potential gap on its offensive line. Right guard Anthony Bradford is questionable with knee and hip injuries. The Seattle Seahawks' official team report identifies Christian Haynes as the next option if Bradford can't play, leaving Lock's protection dependent in part on a late availability decision.
Pick
Seattle Seahawks
Confidence
low
Betting lean
Pass