New Orleans Saints vs Baltimore Ravens Predictions
Sunday, September 20, 2026 at 1:00pm EST at M&T Bank Stadium, Baltimore, MD
Ravens
Who wins this game?
Professional Picks On This Game
Saints vs. Ravens Prediction: Henry Leads Baltimore's Case at -8.5
Analysis updated September 19, 2026 at 11:08 PM CDT
Baltimore is the pick to win. Covering SPF's 8.5-point spread requires more confidence than this matchup warrants.
Henry's production meets offensive line questions
Derrick Henry rushed for 144 yards and three touchdowns on 24 carries in Week 1, according to the New Orleans Saints' official preview. That gives Baltimore a concrete reason to lean on its running game, but SPF's -8.5 spread requires the Ravens to win by at least nine points.
The Baltimore Ravens confirmed that receiver Zay Flowers is out and offensive tackles Ronnie Stanley and guard John Simpson remain questionable. Stanley's and Simpson's availability matters to Baltimore's blocking, while Flowers' absence removes a receiving option if New Orleans slows Henry.
Shough's yards come with a cost
The New Orleans Saints reported that Tyler Shough threw for 410 yards and three touchdowns in their 31-30 overtime loss to Detroit. He also threw two interceptions and lost a fumble. His passing production offers a route to keeping pace; another three giveaways could hand Baltimore chances to build a large lead.
NFL.com lists Saints receiver Chris Olave as questionable with a hamstring injury and Ravens defensive tackle Nnamdi Madubuike as out with a neck injury. Those absences could affect both New Orleans' passing options and Baltimore's run defense, so the injury picture doesn't point cleanly toward Saints +8.5.
The winner pick is Baltimore, with low confidence. At SPF's -380 moneyline, a bet needs roughly a 79.2% win probability to break even. Henry's opener supports the pick, but one game's production doesn't establish that probability or a reliable margin. Pass on the wager; there's no supported score projection.