St. Louis
Cardinals
Moneyline
+158
MLB Predictions
St. Louis Cardinals vs Milwaukee Brewers Predictions
Friday, September 25, 2026 at 7:40pm EST at American Family Field, Milwaukee, Wisconsin
@
Milwaukee
Brewers
Moneyline
-193
50%
50%
Spread
St. Louis Cardinals +1.5
Milwaukee Brewers -1.5
Moneyline
St. Louis Cardinals +158
Milwaukee Brewers -193
Total
Over 7.5 (-114)
Under 7.5 (-105)
Professional Picks
4 listed
Professional Picks On This Game
Tom Strickland
Total pick
Jeff Ross
Money pick
Kevin McHughe
Money pick
Jonah Black
Money pick
Cardinals vs. Brewers Prediction: Pass on Milwaukee at -186
Analysis updated September 25, 2026 at 7:23 AM CDT
The Brewers hold clear advantages in scoring and run prevention, though the matchup between Robert Gasser and Michael McGreevy does not justify laying -186.
Milwaukee’s edge comes at a high price
Milwaukee entered the series with 810 runs and a 3.53 team ERA, while St. Louis had scored 709 runs with a 4.26 ERA. Brew Crew Ball, a Brewers-focused publication, also reported a 3.40 bullpen ERA for Milwaukee compared with 4.50 for St. Louis. Those gaps make the Brewers the likely winner, but SportsPicksForum’s -186 moneyline already charges a substantial premium for their advantages.
McGreevy can keep St. Louis competitive
Cardinals right-hander Michael McGreevy is scheduled to face Brewers left-hander Robert Gasser. McGreevy has a 3.84 ERA and 4.24 FIP across 30 starts, compared with Gasser’s 4.01 ERA and 4.32 FIP. Gasser allowed no more than one run in four of his previous five outings, but the season-long starter numbers don’t create a large enough gap to support Milwaukee at this price.
Betting view
St. Louis at +153 does not offer a strong enough case for an upset, either. Milwaukee is the more likely winner, but the moneyline is too expensive, so the betting lean is Pass.
Pick
Milwaukee Brewers
Confidence
medium
Betting lean
Pass