NFL Predictions

Cleveland Browns vs Jacksonville Jaguars Predictions

Sunday, September 13, 2026 at 1:00pm EST at EverBank Stadium, Jacksonville, FL

Cleveland

Browns

Spread +7.5
@
Jacksonville

Jaguars

Spread -7.5
50% 50%
Spread Cleveland Browns +7.5 Jacksonville Jaguars -7.5
Moneyline Cleveland Browns +300 Jacksonville Jaguars -380
Total Over 40.5 (-110) Under 40.5 (-110)

Who wins this game?

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Browns vs. Jaguars Prediction: Cleveland's Rebuilt Offensive Line Faces Early Test

Analysis updated September 12, 2026 at 6:57 AM CDT

An injury forces another adjustment for Cleveland's rebuilt offensive line as the Browns visit Jacksonville for Sunday's opener.

Cleveland's offensive line faces an immediate test

Cleveland will start five offensive linemen added during the offseason, according to the Cleveland Browns. Austin Barber will replace right guard Teven Jenkins, who's out with a back injury. That makes blocking coordination an early concern against Jacksonville, which SPF lists as a 7.5-point favorite.

The team's injury report also lists center Parker Brailsford as questionable with a thumb injury. If he can't play, Cleveland would need another replacement inside, adding to the adjustments required of this new group.

Prediction and betting decision

NFL.com lists Jacksonville running back LeQuint Allen Jr. as questionable with a hip injury. Tackle Anton Harrison didn't practice, but no game status is listed. His absence from practice alone doesn't establish that he'll miss the game.

Jacksonville is the straight-up pick, with low confidence. Cleveland's offensive line changes give a reason to favor the Jaguars, but don't establish that they'll win by eight or more. At SPF's -380 moneyline, Jacksonville needs to win about 79.2% of the time to break even; the availability reports alone don't justify that estimate. Pass.

SPF lists Cleveland at +300 and the total at 40.5. There's no supported scoring projection to justify an over or under, and passing on Jacksonville doesn't make Cleveland a worthwhile bet.

Pick Jacksonville Jaguars
Confidence low
Betting lean Pass
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