Philadelphia
Eagles
Spread
-7
NFL Predictions
Philadelphia Eagles vs Tennessee Titans Predictions
Sunday, September 20, 2026 at 1:00pm EST at Nissan Stadium, Nashville, TN
@
Tennessee
Titans
Spread
+7
50%
50%
Spread
Philadelphia Eagles -7
Tennessee Titans +7
Moneyline
Philadelphia Eagles -325
Tennessee Titans +260
Total
Over 39.5 (-112)
Under 39.5 (-108)
Who wins this game?
Professional Picks
3 listed
Professional Picks On This Game
Eagles vs. Titans Prediction: Greenard Out as Philadelphia Lays Seven
Analysis updated September 20, 2026 at 5:17 AM CDT
Philadelphia’s defensive availability warrants attention before backing the road favorite at SPF’s -7.
Defensive availability
Philadelphia will face Tennessee without outside linebacker Jonathan Greenard, ruled out with a pectoral injury in NFL.com’s Week 2 injury report. Safety Andrew Mukuba is questionable with a knee injury. Those statuses leave the Eagles short of full defensive availability as SPF asks them to cover seven points.
The same report lists Titans linebacker James Williams as questionable with an elbow injury and cornerback Cordale Flott as questionable with a quad injury. Neither is confirmed out, so Tennessee’s defensive availability also remains unsettled.
Betting outlook
SPF lists Philadelphia at -310 on the moneyline and Tennessee at +250. The Eagles are the tentative straight-up pick based on that market assessment, but the injury report alone doesn't establish a scoring-margin edge or justify paying -310. The call is Pass on either side, including Tennessee +7.
The total is 39.5, with both over and under priced at -110. Defensive injury designations alone don't establish how either offense will perform, so there's no supported total wager.
Pick
Philadelphia Eagles
Confidence
low
Betting lean
Pass