Arizona
Cardinals
Spread
+10.5
NFL Predictions
Arizona Cardinals vs Los Angeles Chargers Predictions
Sunday, September 13, 2026 at 4:25pm EST
@
Los Angeles
Chargers
Spread
-10.5
50%
50%
Spread
Arizona Cardinals +10.5
Los Angeles Chargers -10.5
Moneyline
Arizona Cardinals +410
Los Angeles Chargers -550
Total
Over 46.5 (-110)
Under 46.5 (-110)
Professional Picks
6 listed
Professional Picks On This Game
Tom Strickland
Spread pick
Matt O'Brien
Spread pick
Wes Salvato
Total pick
Frank Obst
Spread pick
Scott Steele
Total pick
Benjamin Sturn
Total pick
Cardinals vs. Chargers: Love Questionable With Arizona Getting 10.5
Analysis updated September 13, 2026 at 5:26 AM CDT
Love's availability is unresolved, and that injury alone doesn't justify backing either side of a double-digit spread.
Love's status and the spread
Arizona running back Jeremiyah Love is questionable with an ankle injury as the Cardinals visit the Chargers as 10.5-point underdogs at SPF. Fantasy sports publication RotoBaller reports that he's expected to play, but says Cardinals coach Mike LaFleur described his status as a game-time decision. His availability remains uncertain, so counting on a full contribution would be premature.
That report doesn't establish how much the injury should affect the margin. Los Angeles must win by at least 11 points to cover, and Love's status alone doesn't support that projection or make Arizona worth backing.
Betting call
SPF lists Los Angeles at -550 and Arizona at +410. The Chargers are the likely winner based on that price, but -550 requires a win probability above 84.6% to break even. There's no supported matchup case for assigning them a higher probability.
The total is 46.5, with both sides priced at -110. Love's ankle report offers too little to project combined scoring. Pass on the moneyline, spread and total; no score prediction.
Pick
Los Angeles Chargers
Confidence
low
Betting lean
Pass