NHL Predictions

Florida Panthers vs Pittsburgh Penguins Predictions

Thursday, October 22, 2026 at 7:00pm EST at PPG Paints Arena, Pittsburgh, PA

Florida

Panthers

5-3-2
Moneyline -105
@
Pittsburgh

Penguins

3-6-1
Moneyline -115
50% 50%
Spread Florida Panthers +1.5 Pittsburgh Penguins -1.5
Moneyline Florida Panthers -105 Pittsburgh Penguins -115
Total Over 6.5 (-125) Under 6.5 (+105)

Who wins this game?

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Florida Panthers vs. Pittsburgh Penguins Prediction: Florida at -105

Analysis updated October 22, 2026 at 7:15 AM CDT

Florida’s stronger start supports a small moneyline lean, but major absences and no confirmed starting goalies make this a cautious play.

Florida’s record creates a narrow edge

Florida enters Thursday’s 7 p.m. EDT matchup at 5-3-2, including 3-2-2 on the road. Pittsburgh is 3-6-1 and has lost four straight, although its 2-1-0 home record helps explain why the Penguins are -115 favorites and the Panthers are -105.

The Canadian Press reports that Florida will be without Aleksander Barkov, Brad Marchand, Jacob Markstrom and Jonah Gadjovich. Pittsburgh has four players ruled out, while Bryan Rust and Samuel Girard are day-to-day. With neither starting goalie confirmed, Florida’s better record supports only a low-confidence moneyline lean.

How the betting market shapes the pick

Wiseguy Team’s DraftKings-reported splits show moneyline tickets divided 50-50, with Florida drawing 54% of the money. That balanced action provides little reason to move away from the matchup evidence or increase confidence.

Florida also leads the NHL with 60 penalty minutes through 10 games. Its discipline creates added risk in a close matchup, but the Panthers at -105 are preferable to paying -115 for a Pittsburgh team on a four-game skid.

The total is 6.5, with the over priced at -135 and the under at +114. The available evidence does not establish how the unconfirmed goalies or depleted lineups will affect scoring, so the total is a pass.

Pick Florida Panthers
Confidence low
Betting lean Florida Panthers moneyline -105
Odds and availability can change. Confirm current markets before placing a wager.
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