Florida Panthers vs Pittsburgh Penguins Predictions
Thursday, October 22, 2026 at 7:00pm EST at PPG Paints Arena, Pittsburgh, PA
Penguins
3-6-1Who wins this game?
Professional Picks On This Game
No professional picks are available for this matchup.
Florida Panthers vs. Pittsburgh Penguins Prediction: Florida at -105
Analysis updated October 22, 2026 at 7:15 AM CDT
Florida’s stronger start supports a small moneyline lean, but major absences and no confirmed starting goalies make this a cautious play.
Florida’s record creates a narrow edge
Florida enters Thursday’s 7 p.m. EDT matchup at 5-3-2, including 3-2-2 on the road. Pittsburgh is 3-6-1 and has lost four straight, although its 2-1-0 home record helps explain why the Penguins are -115 favorites and the Panthers are -105.
The Canadian Press reports that Florida will be without Aleksander Barkov, Brad Marchand, Jacob Markstrom and Jonah Gadjovich. Pittsburgh has four players ruled out, while Bryan Rust and Samuel Girard are day-to-day. With neither starting goalie confirmed, Florida’s better record supports only a low-confidence moneyline lean.
How the betting market shapes the pick
Wiseguy Team’s DraftKings-reported splits show moneyline tickets divided 50-50, with Florida drawing 54% of the money. That balanced action provides little reason to move away from the matchup evidence or increase confidence.
Florida also leads the NHL with 60 penalty minutes through 10 games. Its discipline creates added risk in a close matchup, but the Panthers at -105 are preferable to paying -115 for a Pittsburgh team on a four-game skid.
The total is 6.5, with the over priced at -135 and the under at +114. The available evidence does not establish how the unconfirmed goalies or depleted lineups will affect scoring, so the total is a pass.