NBA Predictions

Cleveland Cavaliers vs Philadelphia 76ers Predictions

Thursday, October 22, 2026 at 7:00pm EST at Xfinity Mobile Arena, Philadelphia, PA

Cleveland

Cavaliers

Spread +2.5
@
Philadelphia

76ers

1-0
Spread -2.5
50% 50%
Spread Cleveland Cavaliers +2.5 Philadelphia 76ers -2.5
Moneyline Cleveland Cavaliers +120 Philadelphia 76ers -142
Total Over 236.5 (-110) Under 236.5 (-110)

Who wins this game?

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Cavaliers vs. 76ers Prediction: Allen’s Status Makes Philadelphia -3.5 a Pass

Analysis updated October 22, 2026 at 7:01 AM CDT

Philadelphia is the likelier winner at home, but the available evidence doesn’t justify laying 3.5 points before the lineups are confirmed.

Allen’s status matters against Embiid

Philadelphia is a 3.5-point home favorite and -148 on the moneyline, while Cleveland is +124. The 76ers are 1-0 after a 106-100 win at New York on October 20. The Cavaliers are playing their season opener.

NBA Official lists Cleveland center Jarrett Allen as questionable with right patellar tendinopathy. His absence would leave the Cavaliers without a projected starter against a Philadelphia lineup expected to include Joel Embiid. Cleveland’s Khalifa Diop and Nae’Qwan Tomlin are out.

Hoops Nightly, a game-day basketball publication, projects Cleveland to start James Harden, Donovan Mitchell, Evan Mobley, Peyton Watson and Allen. It projects Tyrese Maxey, Jaylen Brown, VJ Edgecombe, LeBron James and Embiid for Philadelphia, but notes that starters are usually confirmed about 30 minutes before tip-off.

Prediction and betting view

Philadelphia is the likelier winner at home, but the projected lineups aren’t confirmed and Cleveland has no regular-season results to evaluate. Those limits make the 76ers’ -148 moneyline and 3.5-point spread difficult to justify. Pass before tip-off.

Pick Philadelphia 76ers
Confidence low
Betting lean Pass
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