Denver Broncos vs Kansas City Chiefs Predictions
Monday, September 14, 2026 at 8:15pm EST at Arrowhead Stadium, Kansas City, MO
Chiefs
1-9Professional Picks On This Game
Broncos vs. Chiefs Prediction: Denver +3 Has the Stronger Case
Analysis updated September 14, 2026 at 5:08 AM CDT
Bo Nix's record against Kansas City favors taking the points, though key absences change the matchup for both teams.
Nix's results support Denver +3
Bo Nix has thrown seven touchdown passes and one interception while going 3-1 against Kansas City, according to the Denver Broncos' official team preview. Denver swept both meetings in 2025. That gives the Broncos +3 at SPF a concrete case, though four games aren't enough to make Denver a confident outright pick.
SPF lists Kansas City at -155 and Denver at +130 on the moneyline. The Kansas City Chiefs' official preview reports that Denver went 11-2 in one-possession games last season, compared with Kansas City's 1-9. Those records describe last year's finishes; they don't establish either team's chances of winning this opener.
Kansas City's protection faces a test
The Denver Broncos report that Patrick Mahomes is expected to return after a torn ACL. Kansas City will be missing left tackle Josh Simmons because of a back injury, with a rookie expected to replace him. That adds a protection concern for Mahomes' anticipated return and makes laying three points less appealing.
Denver also loses linebacker Jonathon Cooper, who won't play while on the Commissioner's Exempt List, according to the Kansas City Chiefs. The same report lists defensive tackle Chris Jones without an injury designation despite a calf issue. Those availability details temper the Denver lean: take +3 cautiously, with no outright or exact-score prediction.