Buffalo
Bills
Spread
-3
NFL Predictions
Buffalo Bills vs Minnesota Vikings Predictions
Monday, November 9, 2026 at 8:15pm EST at U.S. Bank Stadium, Minneapolis, MN
@
Minnesota
Vikings
Spread
+3
50%
50%
Spread
Buffalo Bills -3
Minnesota Vikings +3
Moneyline
Buffalo Bills -180
Minnesota Vikings +150
Total
Over 43.5 (-118)
Under 43.5 (-102)
Who wins this game?
Professional Picks
18 available
Professional Picks On This Game
Matt O'Brien
Spread pick
Matt O'Brien
Total pick
Simon Says
Total pick
Wes Salvato
Total pick
Garrett Perry
Spread pick
Scott Steele
Total pick
Charles Avery
Total pick
Primetime Ryan Johnson
Total pick
Franny DiStefano
Spread pick
Franny DiStefano
Total pick
Brooke Smolka
Total pick
Chris Cohen
Spread pick
King Jon Sanderson
Spread pick
Jason Manning
Total pick
Bryan Pratt
Total pick
Ryan Bowland
Total pick
Robert Downes
Spread pick
Robert Downes
Total pick
Bills vs. Vikings Prediction: Minnesota’s QB Absence Favors Buffalo
Analysis updated November 8, 2026 at 8:17 AM CST
The Bills are the likely winners after Minnesota ruled out Kyler Murray, but Buffalo’s injury questions make the road price difficult to back.
Minnesota’s absences favor Buffalo
NFL.com reports that Vikings quarterback Kyler Murray will miss Monday night’s game with a hamstring injury. Minnesota has also ruled out running back Demond Claiborne and wide receiver Jauan Jennings. Those absences favor Buffalo, but the Bills’ -170 moneyline already carries a substantial price. Minnesota is +142, while Buffalo is a 3-point favorite and the total is 43.5.
Both teams enter the game 6-1, but the available evidence doesn’t include confirmed starting lineups, recent results or season statistics. Buffalo is the more likely winner because Murray is out, though the limited matchup data doesn’t support a score projection.
Buffalo’s offensive line adds risk
Buffalo left tackle Dion Dawkins and offensive lineman Alec Anderson are questionable, according to NFL.com. Wide receiver Josh Palmer is out, while Tyrell Shavers, Greg Gaines and Jordan Hancock are also questionable. Dawkins’ and Anderson’s uncertain availability makes Buffalo’s offense harder to assess and weakens the case for laying 3 points on the road.
Buffalo should win, but neither -170 nor Bills -3 offers enough value with the team’s offensive line unsettled. There also isn’t enough evidence to support a bet on the 43.5-point total. The betting lean is Pass.
Pick
Buffalo Bills
Confidence
low
Betting lean
Pass