Cleveland
Guardians
Moneyline
MLB Predictions
Cleveland Guardians vs Boston Red Sox Predictions
Wednesday, September 23, 2026 at 7:00pm EST at Fenway Park, Boston, Massachusetts
@
Boston
Red Sox
Moneyline
50%
50%
Spread
Cleveland Guardians +1.5
Boston Red Sox -1.5
Moneyline
Cleveland Guardians
Boston Red Sox
Total
Over 7 (-119)
Under 7 (-101)
Who wins this game?
Professional Picks
6 available
Professional Picks On This Game
Wes Salvato
Spread pick
Blake Mitchum
Total pick
Joe Napoli
Total pick
Stevie March
Total pick
Dave Vernin
Total pick
Simon Says
Spread pick
Guardians vs. Red Sox Prediction: Gray Gives Boston a Tentative Edge
Analysis updated September 22, 2026 at 11:06 PM CDT
Boston is a tentative winner pick with Sonny Gray listed to start. SPF's -1.5 run line requires more than a win.
Projected pitching matchup
Sonny Gray's 2.82 ERA gives Boston a starting-pitching edge over Cleveland's Foster Griffin at 3.67, if both projected starters take the mound. Cleveland.com, a Northeast Ohio news publication, lists the pair for Wednesday's 7 p.m. ET game at Fenway Park. That supports a tentative Boston pick, but doesn't establish that the Red Sox can cover SPF's -1.5 run line.
Cleveland.com also reports that Cleveland remains without Rhys Hoskins because of a back injury and Boston is without Willson Contreras because of a hand injury. Without confirmed lineups or details on their replacements, those absences don't establish an advantage for either side.
Betting outlook
SPF lists Cleveland at +1.5 and Boston at -1.5, but run-line prices are unavailable. Boston would need to win by at least two runs, and there's no payout to weigh against that requirement. The moneyline price is also unavailable, so pass on a side wager.
The total is 7, with over -119 and under -101. The listed ERAs alone don't justify a total bet without a clearer picture of the lineups and bullpen availability. Pass on the total as well.
Pick
Boston Red Sox
Confidence
low
Betting lean
Pass