Minnesota
Twins
Moneyline
-149
MLB Predictions
Minnesota Twins vs San Francisco Giants Predictions
Wednesday, September 23, 2026 at 3:45pm EST at Oracle Park, San Francisco, California
@
San Francisco
Giants
Moneyline
+123
50%
50%
Spread
Minnesota Twins -1.5
San Francisco Giants +1.5
Moneyline
Minnesota Twins -149
San Francisco Giants +123
Total
Over 7.5 (-118)
Under 7.5 (-102)
Who wins this game?
Professional Picks
1 available
Professional Picks On This Game
Carlos Nunez
Money pick
Twins vs. Giants Prediction: Starter Uncertainty Leaves a Pass at -149
Analysis updated September 22, 2026 at 11:03 PM CDT
Cesar Perdomo is San Francisco’s probable starter, while Minnesota’s remains unlisted, leaving the pitching matchup unresolved.
Pitching matchup and betting impact
Minnesota is a -149 favorite at SPF, but its probable starter remains unlisted in Bay Area Sports Wire’s September 22 update. The Bay Area sports outlet lists left-hander Cesar Perdomo as San Francisco’s probable starter at 0-1 with a 3.72 ERA. Without Minnesota’s starter, there’s no clear pitching comparison to justify backing the favorite.
The Twins’ price requires a win rate of about 59.8% to break even. San Francisco is +124, but knowing its probable starter doesn’t establish an edge at that price either. The moneyline call is Pass.
SPF lists a total of 7.5, with the over at -118 and the under at -102. Perdomo’s ERA alone doesn’t support a scoring projection, so there’s no total wager or score prediction.
Wednesday’s game at Oracle Park is scheduled for 12:45 p.m. PT, or 3:45 p.m. ET, according to Bay Area Sports Wire.
Confidence
low
Betting lean
Pass