NFL Predictions

Philadelphia Eagles vs Chicago Bears Predictions

Monday, September 28, 2026 at 8:15pm EST at Soldier Field, Chicago, IL

Philadelphia

Eagles

Spread -3.5
@
Chicago

Bears

Spread +3.5
50% 50%
Spread Philadelphia Eagles -3.5 Chicago Bears +3.5
Moneyline Philadelphia Eagles -192 Chicago Bears +160
Total Over 41.5 (-110) Under 41.5 (-110)

Who wins this game?

Professional Picks

Professional Picks On This Game

21 available
Staff Preview

Eagles vs. Bears Prediction: Chicago's Quarterback Uncertainty Favors Philadelphia

Analysis updated September 27, 2026 at 7:47 AM CDT

Caleb Williams is out, while Tyson Bagent is questionable and Case Keenum could start for Chicago.

Chicago's quarterback decision drives the matchup

The Philadelphia Eagles are 3.5-point road favorites against the Chicago Bears, with a -198 moneyline and a total of 42.5. Philadelphia is the more likely winner, but Chicago's unconfirmed starting quarterback makes the spread and total difficult to assess.

The Philadelphia Eagles' official injury report ruled out Caleb Williams because of a hamstring injury. Tyson Bagent is questionable with a concussion despite returning to full practice, and the report said Case Keenum could start. Until Chicago names its quarterback, there isn't a sound basis for projecting how often the Bears will score or whether they can stay within 3.5 points.

Philadelphia also has important absences

Philadelphia ruled out wide receiver Marquise Brown, tight end Dallas Goedert and tackle Fred Johnson. Those absences weaken the case for laying points on the road, even with Saquon Barkley and DeVonta Smith available.

The Eagles also listed Jalen Carter, Andrew Mukuba and Tyler Steen as available, while outside linebacker Jonathan Greenard is questionable after practicing fully. Chicago will be without linebacker Noah Sewell and defensive lineman Shemar Turner. The injury advantage still points toward Philadelphia, but it doesn't justify paying -198 without a confirmed Bears starter or reliable evidence on recent form and weather. The betting lean is Pass.

Pick Philadelphia Eagles
Confidence low
Betting lean Pass
Odds and availability can change. Confirm current markets before placing a wager.
Previous Matchups