MLB Predictions

San Francisco Giants vs St. Louis Cardinals Predictions

Wednesday, September 16, 2026 at 1:15pm EST at Busch Stadium, St. Louis, Missouri

San Francisco

Giants

Moneyline +134
@
St. Louis

Cardinals

Moneyline -162
50% 50%
Spread San Francisco Giants +1.5 St. Louis Cardinals -1.5
Moneyline San Francisco Giants +134 St. Louis Cardinals -162
Total Over 8 (-107) Under 8 (-112)

Who wins this game?

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Giants vs. Cardinals Prediction: Probable Starters Give Little Reason to Back St. Louis at -162

Analysis updated September 15, 2026 at 11:01 PM CDT

Both probable starters have ERAs above 5.00, leaving St. Louis without an obvious pitching advantage at SPF's price.

Pitching and price

St. Louis is -162 at SPF despite a probable pitching matchup that offers no clear edge for the favorite. FanDuel Research, FanDuel's sports analysis site, lists Cardinals left-hander Matthew Liberatore with a 5.53 ERA and Giants right-hander Anthony Molina with a 5.24 ERA for Wednesday's game at Busch Stadium. Neither starter is confirmed.

FanDuel Research lists the Cardinals at 75-76 and the Giants at 62-89. That record advantage and home field make St. Louis the tentative winner pick. But -162 requires a win probability of about 61.8% to break even, and those factors alone don't establish that the Cardinals clear that threshold. San Francisco's +134 doesn't become a worthwhile bet simply because the favorite is hard to assess. The moneyline call is Pass.

SPF's total is 8, with over -107 and under -112. The starters' ERAs warrant a look at the over, but they don't establish expected scoring without a fuller view of the batting orders and bullpen availability. With those details unconfirmed, the total is also a pass.

Pick St. Louis Cardinals
Confidence low
Betting lean Pass
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