San Francisco Giants vs St. Louis Cardinals Predictions
Wednesday, September 16, 2026 at 1:15pm EST at Busch Stadium, St. Louis, Missouri
Cardinals
Who wins this game?
Professional Picks On This Game
Giants vs. Cardinals Prediction: Probable Starters Give Little Reason to Back St. Louis at -162
Analysis updated September 15, 2026 at 11:01 PM CDT
Both probable starters have ERAs above 5.00, leaving St. Louis without an obvious pitching advantage at SPF's price.
Pitching and price
St. Louis is -162 at SPF despite a probable pitching matchup that offers no clear edge for the favorite. FanDuel Research, FanDuel's sports analysis site, lists Cardinals left-hander Matthew Liberatore with a 5.53 ERA and Giants right-hander Anthony Molina with a 5.24 ERA for Wednesday's game at Busch Stadium. Neither starter is confirmed.
FanDuel Research lists the Cardinals at 75-76 and the Giants at 62-89. That record advantage and home field make St. Louis the tentative winner pick. But -162 requires a win probability of about 61.8% to break even, and those factors alone don't establish that the Cardinals clear that threshold. San Francisco's +134 doesn't become a worthwhile bet simply because the favorite is hard to assess. The moneyline call is Pass.
SPF's total is 8, with over -107 and under -112. The starters' ERAs warrant a look at the over, but they don't establish expected scoring without a fuller view of the batting orders and bullpen availability. With those details unconfirmed, the total is also a pass.