MLB Predictions

Pittsburgh Pirates vs Chicago White Sox Predictions

Thursday, September 10, 2026 at 7:40pm EST at Rate Field, Chicago, Illinois

Pittsburgh

Pirates

73-73
Moneyline -110
@
Chicago

White Sox

75-70
Moneyline -110
50% 50%
Spread Pittsburgh Pirates -1.5 Chicago White Sox +1.5
Moneyline Pittsburgh Pirates -110 Chicago White Sox -110
Total Over 7.5 (-112) Under 7.5 (-108)

Who wins this game?

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Pirates vs. White Sox prediction: Smith gives Chicago a slight edge

Analysis updated September 10, 2026 at 5:06 AM CDT

Chicago's probable starter has a 0.56 ERA, but Pittsburgh arrives hitting .279 over its last 10 games. SPF lists both teams at -110.

Smith faces a hot Pittsburgh lineup

Hagen Smith gives Chicago the strongest argument at SPF's matching -110 moneylines. StatMuse / Associated Press, which carries the AP matchup preview, lists the left-hander as the probable starter with a 0.56 ERA and 0.94 WHIP. Pittsburgh's probable starter, Jared Jones, has a 4.46 ERA and 1.23 WHIP. Those numbers favor Smith, though his innings total isn't provided, limiting how much weight to put on the gap.

Pittsburgh has gone 8-2 with a .279 batting average over its last 10 games, according to the same preview. Chicago is 3-7 and hitting .205 in that span. The Pirates' recent hitting makes backing Smith less straightforward than the ERA comparison suggests.

Chicago's 43-30 home record tips my winner pick narrowly toward the White Sox. But -110 requires a win rate above 52.4% to break even, and the pitching comparison and recent form don't establish that edge clearly enough. The moneyline is a pass.

Pick Chicago White Sox
Confidence low
Betting lean Pass
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