Louisville
Cardinals
Spread
+6.5
NCAAF Predictions
Louisville Cardinals vs Ole Miss Rebels Predictions
Sunday, September 6, 2026 at 7:30pm EST
@
Ole Miss
Rebels
Spread
-6.5
5%
95%
Spread
Louisville Cardinals +6.5
Ole Miss Rebels -6.5
Moneyline
Louisville Cardinals +210
Ole Miss Rebels -258
Total
Over 55.5 (-108)
Under 55.5 (-112)
Professional Picks
9 listed
Professional Picks On This Game
Tom Strickland
Total pick
Abe Howland
Total pick
Simon Says
Spread pick
Frank Obst
Spread pick
Lane Gibson
Total pick
Danny Soros
Total pick
Scott Steele
Total pick
Percy Walker
Spread pick
Casper Kohke
Total pick
Louisville vs. Ole Miss Prediction: Pass at Rebels -6.5
Analysis updated September 6, 2026 at 5:23 AM CDT
SPF favors Ole Miss, while the early game-day report leaves personnel questions unanswered.
Personnel questions limit the betting case
Neither Louisville nor Ole Miss had released a depth chart when Card Chronicle, a publication covering Louisville sports, posted its game-day report at 5:01 a.m. UTC. That limits personnel analysis for a matchup in which SportsPicksForum makes Ole Miss a 6.5-point favorite.
SPF lists Ole Miss at -258 and Louisville at +210 on the moneyline. The Rebels are the market's likely winner, but -258 requires a win rate above 72.1% to break even. The available matchup reporting doesn't establish that they're worth that price, and the missing depth charts don't make Louisville a value bet.
Betting interest doesn't establish an edge
Betting-splits publisher Fade the Public Analytics reports that Ole Miss drew 95% of moneyline bets and 93% of moneyline money. Those figures show bettor preference, not how often the Rebels should win or cover.
SPF's total is 55.5, with the over at -108 and under at -112. Without verified offensive or defensive performance details to assess scoring, there's no supported total wager. The betting lean is Pass.
Pick
Ole Miss Rebels
Confidence
low
Betting lean
Pass