Detroit
Lions
Spread
+3
NFL Predictions
Detroit Lions vs Buffalo Bills Predictions
Thursday, September 17, 2026 at 8:15pm EST at Highmark Stadium, Orchard Park, NY
@
Buffalo
Bills
Spread
-3
50%
50%
Spread
Detroit Lions +3
Buffalo Bills -3
Moneyline
Detroit Lions +136
Buffalo Bills -162
Total
Over 52.5 (-110)
Under 52.5 (-110)
Professional Picks
21 listed
Professional Picks On This Game
Tom Strickland
Total pick
Matt O'Brien
Spread pick
Matt O'Brien
Total pick
Wes Salvato
Spread pick
Wes Salvato
Total pick
Abe Howland
Spread pick
Abe Howland
Total pick
Frank Obst
Total pick
Jason Manning
Spread pick
Jason Manning
Total pick
Charles Avery
Total pick
Bryan Pratt
Spread pick
Franny DiStefano
Spread pick
Franny DiStefano
Total pick
Lane Gibson
Spread pick
Brooke Smolka
Spread pick
Brooke Smolka
Total pick
Scott Steele
Spread pick
Scott Steele
Total pick
Percy Walker
Spread pick
Percy Walker
Total pick
Lions vs. Bills prediction: Detroit's offensive line injuries favor Buffalo
Analysis updated September 17, 2026 at 5:05 AM CDT
Detroit's confirmed absences give Buffalo the edge in the winner pick. They don't establish value at SPF's Bills -3 or -162 moneyline.
Detroit's offensive line takes two losses
Detroit's offensive line is the clearest concern with Buffalo a 3-point home favorite at SPF. The Detroit Lions ruled out Christian Mahogany with a hip injury and tackle Blake Miller with a knee injury. Those absences reduce Detroit's options up front and make protection a concern, giving Buffalo a low-confidence nod to win.
The Detroit Lions also list cornerback D.J. Reed as questionable with a foot injury. The Buffalo Bills list safety Cole Bishop and defensive lineman T.J. Sanders as questionable, so neither defense's available personnel is settled. Buffalo linebacker Terrel Bernard has no game injury designation despite being limited Wednesday with a calf injury.
Betting outlook
SPF's Buffalo moneyline of -162 requires a win rate of about 61.8% to break even. The injury reports alone don't establish that probability or show that Buffalo should cover -3. Detroit at +136 or +3 isn't an automatic bargain either.
The total is 52.5, with both sides priced at -110. Defensive availability could affect scoring, but there's no supported estimate of either offense's production to justify an over or under. Pass on a wager.
Pick
Buffalo Bills
Confidence
low
Betting lean
Pass