NCAAF Predictions

Louisville Cardinals vs SMU Mustangs

Saturday, November 22, 2025 at 12:00pm EST

Away

Louisville Cardinals

Spread +3.5

Home

Spread -3.5

39%

61%

Spread Louisville Cardinals +3.5 SMU Mustangs -3.5

Moneyline Louisville Cardinals +145 SMU Mustangs -170

Total Over 49.5 (-110) Under 49.5 (-110)

Professional Picks

0 listed

No professional picks are available for this matchup.