NFL Predictions

San Francisco 49ers vs Arizona Cardinals

Sunday, November 16, 2025 at 4:05pm EST

Away

San Francisco 49ers

Spread -3.5

Home

Spread +3.5

57%

43%

Spread San Francisco 49ers -3.5 Arizona Cardinals +3.5

Moneyline San Francisco 49ers -215 Arizona Cardinals +180

Total Over 48.5 (-115) Under 48.5 (-105)

Professional Picks

1 listed

Matt O'Brien Total pick

In Progress