Indianapolis Colts vs Los Angeles Rams

Sunday, September 28, 2025 at 4:05pm EST

Away

Indianapolis Colts

Spread +3.5

Home

Spread -3.5

61%

39%

Spread Indianapolis Colts +3.5 Los Angeles Rams -3.5

Moneyline Indianapolis Colts +160 Los Angeles Rams -190

Total Over 49.5 (-105) Under 49.5 (-115)

Professional Picks

1 listed

Matt O'Brien Total pick

In Progress