NFL Predictions

Jacksonville Jaguars vs San Francisco 49ers

Sunday, September 28, 2025 at 4:05pm EST

Away

Jacksonville Jaguars

Spread +3.5

Home

Spread -3.5

52%

48%

Spread Jacksonville Jaguars +3.5 San Francisco 49ers -3.5

Moneyline Jacksonville Jaguars +145 San Francisco 49ers -170

Total Over 46.5 (-105) Under 46.5 (-115)

Professional Picks

2 listed

Matt O'Brien Total pick

In Progress

Wes Salvato Spread pick

In Progress