MLB Predictions

Houston Astros vs Cleveland Guardians

Tuesday, April 21, 2026 at 6:10pm EST

Away

Houston Astros

Spread +1.5

Home

Spread -1.5

59%

41%

Spread Houston Astros +1.5 Cleveland Guardians -1.5

Moneyline Houston Astros +129 Cleveland Guardians -156

Total Over 8.5 (-122) Under 8.5 (+102)

Professional Picks

1 listed

Allen Barclay Total pick

In Progress

Previous Matchups

4/20 4/21 4/22