Game Date:
12/22/2025
8:15pm EST

Lines:
San Francisco 49ers -5.5
Indianapolis Colts +5.5

Total:
Over 45.5 (-115)
Under 45.5 (-105)

Who do you think will win today? San Francisco 49ers -5.5 or Indianapolis Colts +5.5

Community Picks: San Francisco 49ers 0% vs Indianapolis Colts 0%

Professional Picks On This Game

Matt O'Brien (Spread) Add \| Checkout	Matt O'Brien (Total) Add \| Checkout
Simon Says (Spread) Add \| Checkout	Wes Salvato (Spread) Add \| Checkout
Wes Salvato (Total) Add \| Checkout	Allen Barclay (Spread) Add \| Checkout
King Jon Sanderson (Spread) Add \| Checkout	Frank Obst (Total) Add \| Checkout
Jason Manning (Total) Add \| Checkout	Oliver Peters (Total) Add \| Checkout
Lane Gibson (Spread) Add \| Checkout	Lane Gibson (Total) Add \| Checkout
Chris Cohen (Spread) Add \| Checkout	Chris Cohen (Total) Add \| Checkout
Tom Strickland (Spread) Add \| Checkout	Don Williams (Total) Add \| Checkout
Ryan Bowland (Spread) Add \| Checkout	Ryan Bowland (Total) Add \| Checkout
Brooke Smolka (Spread) Add \| Checkout

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Previous Matchups: 12/22