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San Francisco 49ers
vs
Indianapolis Colts
Today's Featured Sports Pick

Game Date:
12/22/2025
8:15pm EST

Lines:
San Francisco 49ers -4.5
Indianapolis Colts +4.5

Total:
Over 46.5 (-102)
Under 46.5 (-118)

Community Picks: San Francisco 49ers 58% vs Indianapolis Colts 42%

San Francisco 49ers and Indianapolis Colts Thread

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