Game Date:
12/22/2025
8:15pm EST
Lines:
San Francisco 49ers -5.5
Indianapolis Colts +5.5
Total:
Over
45.5 (-115)
Under 45.5 (-105)
Who do you think will win today? San Francisco 49ers -5.5 or Indianapolis Colts +5.5
Community Picks: San Francisco 49ers 0% vs Indianapolis Colts 0%
Professional Picks On This Game
| Matt O'Brien (Spread) Add | Checkout | Matt O'Brien (Total) Add | Checkout | |
| Simon Says (Spread) Add | Checkout | Wes Salvato (Spread) Add | Checkout | |
| Wes Salvato (Total) Add | Checkout | Allen Barclay (Spread) Add | Checkout | |
| King Jon Sanderson (Spread) Add | Checkout | Frank Obst (Total) Add | Checkout | |
| Jason Manning (Total) Add | Checkout | Oliver Peters (Total) Add | Checkout | |
| Lane Gibson (Spread) Add | Checkout | Lane Gibson (Total) Add | Checkout | |
| Chris Cohen (Spread) Add | Checkout | Chris Cohen (Total) Add | Checkout | |
| Tom Strickland (Spread) Add | Checkout | Don Williams (Total) Add | Checkout | |
| Ryan Bowland (Spread) Add | Checkout | Ryan Bowland (Total) Add | Checkout | |
| Brooke Smolka (Spread) Add | Checkout | ||
San Francisco 49ers and Indianapolis Colts Thread
Previous Matchups: 12/22


